Amico Key Ingredient: Phyllanthus niuri

Phyllanthus niuri

is a small tropical plant known being Ayurvedic, Amazonian, Spanish, and Portuguese traditional medicine to treat chronic fever, stomach, spleen, liver, kidney and urinogenital ailments.

Phyllanthus niuri is well known as ‘Chanca piedra’ (Spanish) or ‘Quebra-pedra’ (Portuguese), which means ‘stonebreaker’. It is effective to treat kidney stones {Boin et al., 2010; Pucci et al., 2018} and gallstones {Alok et al., 2013}.

Phyllanthus niuri protects liver from toxin{Manjrekar et al., 2008; Amin et al., 2012}, reduces fatty liver and atherosclerosis thus reduces risks of cardiovascular disease and insulin resistance (type 2 diabetes) {Zarzour et al., 2017}.

Beside hepatic factors of diabetes, Phyllanthus niuri inhibits excessive α-glucosidase and α-amylase activities (reduce GI of diet), thus have direct anti-diabetes importance. {Okoliet al., 2011}

As it protects stomach from gastric acid, studies also discovered that Phyllanthus niuri extract strengthens mucosa tissue from ulceration, haemorrage, edema, and infections {Mostofa et al., 2017}.

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Alok, S., Jain, S.K., Verma, A., Kumar, M. and Sabharwal, M., 2013. Pathophysiology of kidney, gallbladder and urinary stones treatment with herbal and allopathic medicine: A review. Asian Pacific Journal of Tropical Disease3(6), pp.496-504.

Amin, Z.A., Bilgen, M., Alshawsh, M.A., Ali, H.M., Hadi, A.H.A. and Abdulla, M.A., 2012. Protective role of Phyllanthus niruri extract against thioacetamide-induced liver cirrhosis in rat model. Evidence-based complementary and alternative medicine2012.

Boim, M.A., Heilberg, I.P. and Schor, N., 2010. Phyllanthus niruri as a promising alternative treatment for nephrolithiasis. International braz j urol36(6), pp.657-664.

Manjrekar, A.P., Jisha, V., Bag, P.P., Adhikary, B., Pai, M.M., Hegde, A. and Nandini, M., 2008. Effect of Phyllanthus niruri Linn. treatment on liver, kidney and testes in CCl 4 induced hepatotoxic rats.

Mostofa, R., Ahmed, S., Begum, M.M., Rahman, M.S., Begum, T., Ahmed, S.U., Tuhin, R.H., Das, M., Hossain, A., Sharma, M. and Begum, R., 2017. Evaluation of anti-inflammatory and gastric anti-ulcer activity of Phyllanthus niruri L.(Euphorbiaceae) leaves in experimental rats. BMC complementary and alternative medicine17(1), p.267.

Okoli, C.O., Obidike, I.C., Ezike, A.C., Akah, P.A. and Salawu, O.A., 2011. Studies on the possible mechanisms of antidiabetic activity of extract of aerial parts of Phyllanthus niruri. Pharmaceutical biology49(3), pp.248-255.

Pucci, N.D., Marchini, G.S., Mazzucchi, E., Reis, S.T., Srougi, M., Evazian, D. and Nahas, W.C., 2018. Effect of phyllanthus niruri on metabolic parameters of patients with kidney stone: a perspective for disease prevention. International braz j urol44(4), pp.758-764.

Zarzour, A., Hamdan, R., Ahmad, M., Asmawi, M., Kaur, G., Saeed, M.A.A., Al-Mansoub, M.A., Saghir, S.A.M., Usman, N.S., Al-Dulaimi, D.W. and Yam, M.F., 2017. Phyllanthus Niruri Standardized Extract Alleviates the Progression of Non-Alcoholic Fatty Liver Disease and Decreases Atherosclerotic Risk in Sprague–Dawley Rats. Nutrients9(7), p.766.

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